Cadence

Cadence: supervised AI agents for chronic disease care

Cadence is a clinical AI company that automates the routine, protocol-driven work of chronic care management — medication titrations, symptom checks, lifestyle coaching, and care coordination — using AI agents that operate under clinician supervision. The platform tracks patient vitals, symptoms, medications, and engagement to flag risk early, resolves what can be handled by protocol, and escalates to physicians only when needed. In practice, 99% of alerts are resolved without physician escalation.

Cadence sells to health systems and hospital networks and embeds directly into existing EMR workflows, so PCPs and specialists keep control of their patients while offloading day-to-day monitoring. It runs three care models: 24/7 preventive primary care covered by Medicare, remote patient care built on daily vitals monitoring, and post-acute care aimed at cutting readmissions. The company works alongside more than 20 health systems and treats over 100,000 active patients, primarily older adults with conditions such as heart failure, hypertension, type 2 diabetes, and COPD.

Key Features

• Supervised AI agents that automate medication titration, symptom checks, coaching, and care coordination under clinical protocols
• Continuous clinical intelligence across vitals, symptoms, medications, and engagement to catch deterioration early
• Direct EMR integration so care fits existing physician workflows
• Three care models: 24/7 preventive primary care, remote patient monitoring, and post-acute care
• Validated outcomes: 27% reduction in hospital admissions and $1,302 lower annual cost of care per patient
• Peer-reviewed evidence published in Mayo Clinic Proceedings, NEJM Catalyst, and JACC: Advances

Ideal Use Case

Cadence fits health systems that carry large chronic-disease populations and cannot hire enough care managers to monitor them. It is designed for organizations moving into value-based care that need documented outcomes — fewer admissions, better guideline adherence, lower total cost — without adding clinician workload.

How Cadence differentiates

Cadence pairs automation with published clinical evidence rather than marketing claims: peer-reviewed results include a 230% increase in heart failure patients on guideline-directed medical therapy and a 70% relative improvement in blood pressure control. In June 2026 it raised a $100M Series C led by Spark Capital, with Thrive Capital, General Catalyst, Coatue, B Capital, Corewell Health Ventures, Memorial Hermann, and Duke Health participating. Named health system partners include Duke Health, Providence, Montefiore Einstein, Yale New Haven Health, Rush, and Texas Health Resources, and the company reports saving Medicare roughly $2.7 million per week.

FAQ

What is Cadence? A clinical AI platform whose supervised agents automate chronic care management for health systems, keeping physicians in control.

What conditions does Cadence manage? Chronic conditions in older adults, including congestive heart failure, hypertension, type 2 diabetes, and COPD.

Is Cadence a consumer app? No. Cadence partners with health systems; patients are enrolled through their own physicians and monitored with connected devices.

How much does Cadence cost? Pricing is negotiated with health systems and payers; several programs are reimbursed by Medicare. Contact Cadence for details.

tl;dr

Cadence automates chronic disease care with clinician-supervised AI agents across 20+ health systems and 100,000+ patients. $100M Series C led by Spark Capital in June 2026, with outcomes published in peer-reviewed journals.

Related

Looking for more options? Browse the Healthcare directory or read our best AI healthcare tools listicle. Cadence is also tracked on Crunchbase.